Description

Post Doctoral Position Singh Lab
Med-Immunology - Pennsylvania-Pittsburgh - (25006890)

Your research will build upon ongoing efforts to analyze the molecular encoding of memory in macrophages and T cells, as well as its functional consequences for both innate and adaptive immune responses. The proposed work will leverage expertise in single-cell and single-molecule analyses, as well as utilize experimental and computational tools, the latter enabling predictions of DNA sequences that dictate memory-specific alterations in chromatin structure at single-base pair resolution. Changes in these research plans may occur and will be based on mutual discussions with Drs. Gottschalk and Singh of evolving research priorities and experimental progress.

Responsibilities include using computational approaches to predict DNA sequence features that dictate immune memory and experimentally investigating the underlying mechanisms. Approaches used in this role will include assays for transposase-accessible chromatin with sequencing (ATAC-Seq), single-cell transcriptomic analyses, CRISPR-mediated perturbation, and the development of gene regulatory networks.

Qualifications

Candidate must have a Ph.D. or equivalent degree in biomedical sciences. Qualifications include expertise in single-cell and transcriptomic analyses in primary immune cells.

The University of Pittsburgh is an equal opportunity employer / disability / veteran.

Assignment Category: Full-time regular
Campus: Pittsburgh
Child Protection Clearances: Not Applicable
Required Attachments: Curriculum Vitae

Assignment Category Full-time regular

PI281222786