Description

Postdoctoral Research Fellow, Center for Translational Cancer Research, The Brown Foundation Institute of Molecular Medicine

The Lyu Lab is recruiting a highly motivated Postdoctoral Fellow to join a new and well-funded research program focused on cancer stress responses, proteostasis, and cancer therapeutic resistance. The lab is supported by funding from CPRIT and UTHealth, providing an exceptional platform for innovative basic and translational cancer research.

Recruited through a CPRIT Recruitment Award, Dr. Xiangdong Lyu joined UTHealth as a tenure-track Assistant Professor in 2025. He is affiliated with The University of Texas MD Anderson Cancer Center / UTHealth Graduate School of Biomedical Sciences (GSBS) through the Cancer Biology Program and Molecular & Translational Biology Program. Before that, Dr. Lyu conducted research as a DOD Breakthrough Fellowship Awardee at Baylor College of Medicine and MD Anderson Cancer Center. Dr. Lyu received his Ph.D. from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, and his B.S. degree from Shandong University.

The Lyu lab studies how cancer cells sense and response to stresses arising from the tumor microenvironment and therapeutic interventions. Our research aims to define the molecular mechanisms that drive tumorigenesis and resistance to targeted therapy and chemotherapy, with the ultimate goal of developing mechanism-based strategies to overcome these resistances. Dr. Lyu has published multiple first/co-first author papers in prestigious journals, such as: Science (PMID: 37676964), PLoS Biology (PMID: 24302888), Cell Research (PMID: 27002220), Development (PMID: 37013244), Journal of Biological Chemistry (PMID: 23532857), which have been highlighted in Nature Reviews Drug Discovery, Cancer Discovery, Cell Chemical Biology, and The Innovation. More information: https://gsbs.uth.edu/directory/profile?id=40d9e532-06b6-4357-b9c1-3e2d87d351dd .

Position Key Accountabilities:

1. Plans and conducts experiments, analyzes data, and prepares publications describing results.
2. Assists in training and mentoring of lab personnel, including graduate students and other trainees.
3. Reads and evaluates literature.
4. Possess interpersonal skills to effectively collaborate and communicate with individuals at all levels.
5. Have strong written and oral communication skills.
6. Performs other duties as assigned.

What we do here changes the world. UTHealth Houston is Texas' resource for healthcare education, innovation, scientific discovery, and excellence in patient care. That's where you come in.

Once you join us you won't want to leave. It's because we reward our team for the excellent service they provide. Our total rewards package includes the benefits you'd expect from a top healthcare organization (benefits, insurance, etc.), plus:

• 100% paid medical premiums for our full-time employees
• Generous time off (holidays, preventative leave day, both vacation and sick time - all of which equates to around 37-38 days per year)
• The longer you stay, the more vacation you'll accrue!
• Build your future with our awesome retirement/pension plan!

We take care of our employees! As a world-renowned institution, our employees' wellbeing is important to us. We offer work/life services such as...

• Free financial and legal counseling
• Free mental health counseling services
• Gym membership discounts and access to wellness programs
• Other employee discounts including entertainment, car rentals, cell phones, etc.
• Resources for child and elder care
• Plus many more!

Position Summary:

A biomedical postdoc position provides an opportunity for early-career researchers to gain valuable experience, develop independent research skills, and contribute to the advancement of scientific knowledge in their field of expertise.

Position Key Accountabilities:

1. Plans and conducts experiments, analyzes data, and prepares publications describing results.
2. Assists in training and mentoring of lab personnel, including graduate students and other trainees.
3. Reads and evaluates literature.
4. Possess interpersonal skills to effectively collaborate and communicate with individuals at all levels.
5. Have strong written and oral communication skills.
6. Performs other duties as assigned.

We welcome highly motivated individuals to join us!

Candidates must hold a recent Ph.D. and/or M.D., with a preferred background in molecular biology, biochemistry, cell biology, and/or cancer biology.

Minimum Education:

Doctoral/Terminal Degree

Physical Requirements:

Exerts up to 20 pounds of force occasionally and/or up to 10 pounds frequently and/or a negligible amount constantly to move objects.

Security Sensitive:

This job class may contain positions that are security sensitive and thereby subject to the provisions of Texas Education Code § 51.215

Residency Requirement:

Employees must permanently reside and work in the State of Texas.